. Author manuscript; available in PMC: 2009 May 4.

Published in final edited form as: Mol Pharm. 2008 Jul 29;5(5):829–838. doi: 10.1021/mp800043n

Table 1.

Antiproliferative Effects of Laulimalide Analogues (n = 3)

	IC₅₀ ± SD (μM)
laulimalide analogue	MDA-MB-435	NCI/ADR^a	1A9	PTX10^b
LA13	7.9 ± 0.320	22.9 ± 0.090(2.9)	ND^c	ND
LA14	1.2 ± 0.091	1.2 ± 0.099(1.0)	1.0 ± 0.021	1.8 ± 0.027(1.8)
LA15	1.35 ± 0.05	2.38 ± 0.09 (1.8)	1.42 ± 0.32	3.49 ± 0.16 (2.5)
LA16	7.30 ± 1.27	12.4 ± 1.4 (1.7)	7.91 ± 0.64	16.4 ± 4.4 (2.1)
LA17	>50	ND	ND	ND
LA18	0.233 ± 0.02	0.433 ± 0.04 (1.9)	0.424 ± 0.02	1.11 ± 0.10 (2.6)

The relative resistance values shown in parentheses were calculated by dividing the IC₅₀ values of the resistant line NCI/ADR by the sensitive cell line MDA-MB-435.

The relative resistance values shown in parentheses were calculated by dividing the IC₅₀ values of resistant cell line PTX10 by the IC₅₀ obtained in the parental 1A9.

Not determined.