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Median (interquartile range) activated CD8+ cell counts (CD8+/CD38+/HLA-DR+) percentages (A) and absolute counts (B) by baseline CD4+ stratum over time for patients who underwent comprehensive immunological assessments by advanced flow cytometry. The shaded area reflects the lowest and highest interquartiles of the 2 age groups of HIV-negative control subjects (from AIDS Clinical Trials Group protocol A5113) [33].
