TABLE 3.
Interactions between dietary patterns and the genetic risk score in relation to diabetes risk1
| Dietary patterns3 |
||||||
| Genetic risk score2 | Q1 (lowest) | Q2 | Q3 | Q4 (highest) | P for trend | P for interaction |
| Western dietary pattern | ||||||
| <10 (n = 503) | 1 | 0.79 (0.46, 1.38) | 0.81 (0.48, 1.37) | 1.07 (0.65, 1.76) | 0.69 | 0.02 |
| 10–11 (n = 904) | 1 | 0.98 (0.67, 1.44) | 1.02 (0.69, 1.49) | 1.40 (0.97, 2.01) | 0.06 | — |
| ≥12 (n = 1126) | 1 | 1.23 (0.88, 1.73) | 1.49 (1.06, 2.09) | 2.06 (1.48, 2.88) | 0.01 | — |
| Prudent dietary pattern | ||||||
| <10 (n = 503) | 1 | 0.85 (0.50, 1.44) | 1.07 (0.65, 1.76) | 1.29 (0.79, 2.11) | 0.24 | NS |
| 10–11 (n = 904) | 1 | 0.75 (0.52, 1.07) | 0.81 (0.56, 1.18) | 0.77 (0.53, 1.11) | 0.21 | — |
| ≥12 (n = 1126) | 1 | 0.81 (0.58, 1.14) | 0.71 (0.51, 0.99) | 0.81 (0.59, 1.13) | 0.16 | — |
1
The analyses were adjusted for age, BMI, smoking, alcohol consumption, physical activity, family history of diabetes, and total energy intakes. Q, quartile.
2
Defined by counting the number of risk alleles of 10 single nucleotide polymorphisms from a genomewide association study, including HHEX (rs1111875), CDKAL1 (rs7756992), IGF2BP2 (rs4402960), SLC30A8 (rs13266634), WFS1 (rs10010131), CDKN2A/B (rs564398, rs10811661), TCF7L2 (rs12255372), PPARG (rs1801282), and KCNJ11 (rs5219).
3
Values are odds ratios (95% CIs) calculated by using an unconditional logistic regression model.