Skip to main content
. 2009 Mar 25;89(5):1459–1467. doi: 10.3945/ajcn.2008.27265

TABLE 2.

Bone mineral density (BMD) and circulating concentrations of bone turnover markers during the 1-y randomized controlled trial1

Men (n = 55)
 Women (n = 58)
Baseline 6 mo 12 mo P for interaction2 Baseline 6 mo 12 mo P for interaction2
BMD (g/cm2)
 Lumbar spine
  DHEA 1.139 ± 0.029 1.156 ± 0.030 1.157 ± 0.0283 1.065 ± 0.029 1.083 ± 0.0314 1.085 ± 0.0314
  Placebo 1.139 ± 0.031 1.149 ± 0.031 1.153 ± 0.0323 0.61 1.016 ± 0.029 1.029 ± 0.030 1.024 ± 0.030 0.03
 Total hip
  DHEA 1.031 ± 0.024 1.025 ± 0.024 1.026 ± 0.024 0.896 ± 0.022 0.897 ± 0.022 0.894 ± 0.022
  Placebo 1.015 ± 0.018 1.014 ± 0.019 1.015 ± 0.019 0.42 0.881 ± 0.023 0.873 ± 0.023 0.874 ± 0.023 0.09
 Femoral neck
  DHEA 0.805 ± 0.020 0.805 ± 0.021 0.806 ± 0.023 0.749 ± 0.022 0.743 ± 0.021 0.751 ± 0.023
  Placebo 0.812 ± 0.020 0.809 ± 0.021 0.815 ± 0.022 0.81 0.727 ± 0.020 0.726 ± 0.019 0.733 ± 0.023 0.74
 Trochanter
  DHEA 0.825 ± 0.023 0.817 ± 0.022 0.820 ± 0.023 0.680 ± 0.016 0.683 ± 0.017 0.687 ± 0.018
  Placebo 0.810 ± 0.018 0.812 ± 0.018 0.811 ± 0.018 0.16 0.668 ± 0.021 0.665 ± 0.021 0.666 ± 0.021 0.21
 Whole-body
  DHEA 1.273 ± 0.027 1.275 ± 0.027 1.275 ± 0.027 1.136 ± 0.022 1.133 ± 0.023 1.148 ± 0.024
  Placebo 1.279 ± 0.025 1.283 ± 0.024 1.287 ± 0.025 0.88 1.108 ± 0.024 1.108 ± 0.024 1.107 ± 0.024 0.16
Bone turnover markers
 CTX (ng/mL)5
  DHEA 0.354 ± 0.022 — 0.361 ± 0.032 0.422 ± 0.034 — 0.357 ± 0.0303
  Placebo 0.344 ± 0.027 — 0.380 ± 0.046 0.52 0.550 ± 0.057 — 0.477 ± 0.0503 0.81
 BAP (U/L)
  DHEA 20.0 ± 1.2 — 18.1 ± 1.03 24.8 ± 1.7 — 20.9 ± 1.33
  Placebo 19.6 ± 0.9 — 18.7 ± 0.93 0.27 28.1 ± 2.4 — 24.3 ± 1.43 0.85
1

All values are arithmetic means ± SEs. CTX, C-terminal telopeptide of type I collagen; BAP, bone-specific alkaline phosphatase; DHEA, dehydroepiandrosterone.

2

P for group × time interaction from repeated-measures ANCOVA, which included baseline values as a covariate.

3

P < 0.05 based on main effect of time, which was only tested in the absence of a significant group × time interaction.

4

Significantly different from baseline (within group and sex), P ≤ 0.05 (Tukey test).

5

To convert to nmol/L (SI units), multiply values by 7.750.