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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Genes Brain Behav. 2008 Oct;7(7):810–820. doi: 10.1111/j.1601-183X.2008.00428.x

Figure 1. Chr21 proteins: direct and indirect interactions with NMDAR and signaling consequences.

Figure 1

Chr21 proteins are shown in shaded boxes: DYRK1a, dual specificity tyrosine protein kinase; SYJN1, synaptojanin 1, phosphoinositol phosphatase; TIAM1, transient invasion and metastasis protein 1, a guanine nucleotide exchange factor specific for Rac; ITSN1, Intersectin 1, a multi-domain, multifunctional protein; PCP4, Purkinje Cell Protein 4; RCAN 1, Regulator of calcineurin 1; APP, Amyloid Precursor protein; SOD1, Superoxide Dismutase 1; BACH1, BTB and CNC homology transcription factor 1. CaN, calcinuerin, a calcium-calmodulin-dependent protein phosphatase; CaM, calmodulin. PtdIns, phosphatydylinositol. Arrows, activation; blunt lines, inhibition; straight lines, interaction. Solid lines direct, dashed lines, indirect effects. (1)Ahn et al 2006a, (2) Kelly & Rahmani, 2005 (3) Adayev et al 2006, (4) Fleming et al 2004, (5) Mertens et al 2003, (6) Tolias et al 2007, (7) Zhang & Macara, 2006, (8) Wang et al 2007, (9) Papadia & Hardingham 2007, (10) Snyder et al 2005, (11) Nishimura et al 2006, (12) Mohney et al 2003, (13) Choe et al 2005, (14) Sugimoto et al 1997, (15) Tain & Karin 1999, (16) Putkey et al 2004, (17) Hoeffer et al 2007, (18) Rothermel et al 2003, (19) Winder & Sweatt 2001, (20) Ermak et al 2006, (21) Lott et al 2006, (22) Reichard et al 2007, (23) Fleming et al 1998, (24) Woods et al 2001, (25) Das et al (2007), (26) Yamabhai et al (1998).