Table 2.

Average protein levels in hippocampus for each genotype-treatment group

	Naive		+0.4 mg/kg MK-801		+0.8 mg/kg MK-801
	Ts65Dn	Ts1Cje	Ts65Dn	Euploid	Ts1Cje	Euploid
Chr21
TIAM1,p2	101±15	98±15	115±30	97±16	87±13	95±16
TIAM1,s	168±23 **	117±21	86±8	107±12	88±15	107±13
DYRK1A,p2	113±13	124±4 ***	143±27	131±33	78±18 **	74±6 **
DYRK1A,s	141±19 *	106±18	96±17	117±17	95±11	105±15
Non-chr21
tNR1,p2	95±14	93±7	109±25	98±25	88±9	99±7
pNR1,p2	100±11	101±10	106±10	99±10	141±11 **	137±6 **
tAkt	88±12	103±6	96±8	106±11	104±10	117±17
pAkt	139±13 ***	113±21	121±14	94±7	88±15	107±13
tErk1,s	nd	105±11	nd	nd	96±21	108±15
pErk1,s	160±27 *	128±10 *	89±10	106±6	85±11 *	107±10
tErk2,s	nd	105±12	nd	nd	99±18	106±11
pErk2,s	148±20 *	172±19 ***	102±19	110±11	68±8 ***	117±13
pElk,s	138±12 *	104±12	87±13	95±16	91±19	95±13

Values (average plus SEM) of naive mice are relative to 100 for euploid controls. Values + MK-801 are relative to the same genotype without MK-801 treatment. Bold indicates significant differences, Tukey's t-test

^*p<0.05

^**p<0.01

^***p<0.001

^p2crude membrane fraction

^ssoluble fraction

^ndnot determined