Table 4.
Rate Ratios of All-Cause and CVD Mortality by 25(OH)D† Quartiles in 13,331 participants of NHANES III.
| All-Cause Mortality Rate Ratio |
>32.1 ng/ml | 24.4-32.1 ng/ml | 17.8-24.4 ng/ml | <17.8 ng/ml |
|---|---|---|---|---|
| Unadjusted | 1.0 (Ref) | 1.14 (0.94-1.39) | 1.49 (1.24-1.78) | 1.78 (1.44-2.21) |
| Limited* | 1.0 (Ref) | 0.92 (0.78-1.08) | 1.11 (0.95-1.31) | 1.52 (1.31-1.77) |
| Full** | 1.0 (Ref) | 0.93 (0.79-1.10) | 1.06 (0.89-1.24) | 1.26 (1.08-1.46) |
| Full without diabetes mellitus and hypertension |
1.0 (Ref) | 0.94 (0.80-1.12) | 1.06 (0.90-1.26) | 1.28 (1.11-1.48) |
|
CVD Mortality Rate Ratio |
>32.1 ng/ml | 24.4-32.1 ng/ml | 17.8-24.4 ng/ml | <17.8 ng/ml |
| Unadjusted | 1.0 (Ref) | 1.07 (0.82-1.41) | 1.31 (1.01-1.71) | 1.70 (1.22-2.37) |
| Limited* | 1.0 (Ref) | 0.85 (0.67-1.09) | 0.98 (0.76-1.27) | 1.53 (1.12-2.08) |
| Full** | 1.0 (Ref) | 0.83 (0.65-1.07) | 0.88 (0.69-1.14) | 1.20 (0.87-1.64) |
| Full without diabetes mellitus and hypertension |
1.0 (Ref) | 0.85 (0.66-1.09) | 0.89 (0.69-1.15) | 1.22 (0.90-1.65) |
|
Cancer Mortality Rate Ratio |
>32.1 ng/ml | 24.4-32.1 ng/ml | 17.8-24.4 ng/ml | <17.8 ng/ml |
| Unadjusted | 1.0 (Ref) | 0.97 (0.65-1.45) | 1.52 (1.10-2.10) | 1.31 (0.96-1.81) |
| Limited* | 1.0 (Ref) | 0.78 (0.53-1.16) | 1.11 (0.82-1.51) | 1.05 (0.74-1.47) |
| Full*** | 1.0 (Ref) | 0.80 (0.54-1.19) | 1.08 (0.80-1.46) | 0.91 (0.63-1.31) |
|
Infectious Disease Mortality Rate Ratio |
>32.1 ng/ml | 24.4-32.1 ng/ml | 17.8-24.4 ng/ml | <17.8 ng/ml |
| Unadjusted | 1.0 (Ref) | 1.28 (0.65-2.53) | 1.22 (0.67-2.21) | 1.46 (0.73-2.91) |
| Limited* | 1.0 (Ref) | 1.06 (0.53-2.12) | 0.90 (0.46-1.76) | 1.10 (0.47-2.56) |
| Full** | 1.0 (Ref) | 1.01 (0.53-1.93) | 0.87 (0.43-1.74) | 0.84 (0.38-1.86) |
|
External Causes of Death Rate Ratio |
>32.1 ng/ml | 24.4-32.1 ng/ml | 17.8-24.4 ng/ml | <17.8 ng/ml |
| Unadjusted | 1.0 (Ref) | 0.88 (0.25-3.08) | 1.59 (0.58-4.37) | 1.17 (0.44-3.07) |
| Limited* | 1.0 (Ref) | 0.85 (0.26-2.83) | 1.47 (0.54-3.99) | 1.05 (0.45-2.48) |
| Full*** | 1.0 (Ref) | 0.92 (0.27-3.11) | 1.68 (0.63-4.47) | 1.27 (0.56-2.87) |
†
To convert to SI units, multiply 25(OH)D value by 2.496.
*
Limited Model adjusted for age, sex, race, and season
**
Fully Adjusted Model includes age, sex, race, season, hypertension, history of prior CVD, diabetes, smoking, HDL cholesterol, total cholesterol, use of cholesterol medications, eGFR categories, serum albumin, log(albumin-creatinine ratio), log(CRP), BMI, physical activity level, vitamin D supplementation and low SES.
***
Fully Adjusted Cancer and External Causes of Death Models include age, sex, race, season, cigarette use, BMI, log (CRP), serum albumin, physical activity level, vitamin D supplementation and low SES.