Table 2.

VLPs produced in plants

Antigen	Expression system	Highest Yield	VLP proof	Ref.
S-HBsAg	Transgenic tobacco	0.01% TSP leaf	G, EM	[49]
	Transgenic potato	16 μg/g tuber	EM	[52]
	Transgenic lupine callus	150 ng/g FW	ND	[50]
	Transgenic lettuce	5.5 ng/g leaf	ND	[50]
	Transgenic tobacco cells	2 μg/g of FW	G	[54]
		8 μg/g FW	G, EM	[53]
	Transgenic cherry tomatillo	10 ng/g FW fruit	ND	[51]
	Transgenic soybean cells	74 μg/g FW	G, EM	[53]
M-HBsAg	Transgenic N. benthamiana	394 ng/mg TSP leaf	G	[67]
	Transgenic potato	15 ng/mg TSP tuber	ND	[68]
		0.09% TSP tuber	ND	[69]
VSPá-S-HBsAg	Transgenic tobacco cells	226 ng/mg TSP	G	[57]
GFP-HBsAg	Transient/N. benthamiana	25 ng/mg TSP leaf	G, EM	[58]
HBcAg	Transgenic tobacco	24 μg/g FW leaf	EM	[76]
	PVX/ N. benthamiana	50 μg/g leaf	EM	[40]
	CPMV/cowpea	10 μg/g leaf	EM	[40]
	MagnICON/ N. benthamiana	2 mg/g FW leaf	G, EM	[78]
NVCP	Transgenic tobacco	0.23% of TSP leaf	EM, 38nm	[84]
	Transgenic potato	10–20 μg/g tuber	ND	[84]
	Transgenic tomato	20–30 μg/g dry fruit	G	[67]
	MagnICON/ N. benthamiana	0.8 mg/g FW leaf	G, EM	[UR]
HPV11-L1	Transgenic potato	20 ng per g tuber	EM	[95]
HPV16 L1	Transgenic tobacco	0.5% of TSP leaf	G	[97]
	Transgenic potato	0.2% of TSP tuber	G, EM	[97]
	Transgenic tobacco	2–4 μg/kg FW leaf	EM	[95]
	MagnICON/ N. benthamiana	86 μg/g FW leaf	ND	[UR]

Abbreviation used: TSP, total soluble protein; FW, fresh weight; G, gradient; EM, electron microscopy; ND, not determined; UR unpublished result.