Table 2.
Characteristics of Patients with ONJ
| Cancer diagnosis | Age (yr)/sex | Time to ONJ (mo) | Type of bisphosphonate (cumulative dose, mg) | Oral findings and interventions |
| 1. Breast cancer | 60/F | 17 | Zoledronic acid (48) | Dental extraction |
| 2. Breast cancer | 70/F | 41 | Pamidronate (1800) | Periodontal disease, dental extraction |
| Zoledronic acid (44) | ||||
| 3. Breast cancer | 42/F | 7 | Zoledronic acid (28) | Dental extraction, bone exostosis |
| 4. Breast cancer* | 45/F | 24 | Pamidronate (1530) | Trauma, bone exostosis |
| Zoledronic acid (44) | ||||
| 5. Breast cancer | 61/F | 17 | Pamidronate (90) | Periodontal disease, dental extraction |
| Zoledronic acid (128) | ||||
| 6. Breast cancer | 69/F | 51 | Pamidronate (1710) | Dental extraction |
| Zoledronic acid (108) | ||||
| 7. Breast cancer | 46/F | 38 | Pamidronate (810) | Periodontal disease, dental abscess |
| Zoledronic acid (84) | ||||
| 8. Breast cancer | 63/F | 54 | Pamidronate (2790) | Periodontal disease, dental extraction |
| Zoledronic acid (76) | ||||
| 9. Breast cancer* | 78/F | 19 | Zoledronic acid (72) | Periodontal disease, dental extraction |
| 10. Breast cancer | 63/F | 25 | Zoledronic acid (32) | Periodontal disease, dental extraction, trauma |
| 11. Breast cancer | 60/F | 66 | Pamidronate (2700) | Periodontal disease, dental extraction |
| Zoledronic acid (132) | ||||
| 12. Breast cancer | 62/F | 39 | Pamidronate (1710) | Bone exostosis |
| Zoledronic acid (72) | ||||
| 13. Breast cancer* | 47/F | 39 | Pamidronate (3510) | Periodontal disease |
| 14. Breast cancer* | 64/F | 23 | Pamidronate (1980) | Dental Infection |
| 15. Breast cancer* | 63/F | 68 | Pamidronate (900) | Dental extraction |
| Zoledronic acid (64) | ||||
| 16. Breast cancer* | 60/F | 4 | Zoledronic Acid (8) | Bone exostosis† |
| 17. Myeloma | 79/F | 27 | Pamidronate (1260) | Dental extraction, bone exostosis |
| Zoledronic acid (32) | ||||
| 18. Myeloma | 67/M | 56 | Pamidronate (2520) | Periodontal disease, bone exostosis |
| Zoledronic acid (60) | ||||
| 19. Myeloma | 61/M | 4 | Pamidronate (360) | Bone exostosis, periodontal disease, dental extraction |
| 20. Myeloma | 71/F | 12 | Zoledronic acid (44) | Trauma |
| 21. Myeloma | 51/F | 19 | Zoledronic acid (56) | None |
| 22. Myeloma | 53/F | 28 | Pamidronate (1800) | Bone exostosis |
| 23. Myeloma | 63/M | 7 | Zoledronic acid (28) | Dental extraction, periodontal disease, periodontal surgery |
| 24. Myeloma | 42/M | 66 | Pamidronate (2520) | Bone exostosis |
| Zoledronic acid (144) | ||||
| 25. Myeloma* | 50/M | 20 | Pamidronate (1800) | Bone exostosis |
| 26. Myeloma | 64/M | 33 | Pamidronate (90) | Periodontal disease, dental extraction |
| Alendronate | ||||
| 27. Myeloma | 49/M | 39 | Zoledronic acid (152) | Dental extraction, dental decay |
| 28. Myeloma | 64/F | 47 | Pamidronate (2430) | Periodontal disease, trauma |
| Zoledronic acid (72) | ||||
| 29. Myeloma* | 66/M | 8 | Pamidronate (720) | Periodontal disease, dental extraction, trauma |
* Patients deceased.
† Patient with extensive metastatic breast cancer diagnosed in February 2003. Started on zoledronic acid March 2003. Unknown oral status before presentation to dental clinic with exposed bone in the left mandible in July 2003. Deceased in February 2004.