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Effect of mechanical skeletal loading on new bone formation in Gja1+/flox wildtype (WT), Gja1–/flox heterozygous (HET), and ColCre;Gja1−/flox conditional knockout (CKO) mice. Data are expressed as the difference between loaded and unloaded tibia for (A) mineral apposition rate (MAR), (B) mineralizing surface (MS), and (C) bone formation rate (BFR/BS) in each genotype. a p < 0.05 vs. WT; b p < 0.05 vs. WT and HET.
