Table 2. Up-Regulated Genes in JAK/STAT Pathway by CD56⁺ T Supernatant.

Gene array analysis of CD56⁺ T SN-regulated genes in JAK/STAT pathway in primary human hepatocytes Primary human hepatocytes were incubated with or without CD56⁺ T SN (50%, v/v) for 6h. Total RNA was harvested and subjected to the gene array using RT² ProfilerTM PCR Array System (SuperArray Bioscience Corporation). Data analysis was performed using Data-Analysis-Template from Superarray Bioscience Corporation. The genes which displayed less than 2-fold up- or down-regulation relative to that of the control group were omitted. The CD56⁺ T SN up-regulated about 24 genes (Table 2) and down-regulated 10 genes (Table 3) over 2-fold in JAK/STAT pathway.

Gene	Description	Fold
CXCL9	Chemokine (C-X-C motif) ligand 9	112.99
NOS2A	Nitric oxide synthase 2A (inducible, hepatocytes)	73.01
IFNG	Interferon, gamma	43.41
IL2RA	Interleukin 2 receptor, alpha	31.34
GBP1	Guanylate binding protein 1, interferon-inducible, 67kDa	22.78
CSF2RB	Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	12.21
IRF-1	Interferon regulatory factor 1	11.08
IL20	Interleukin 20	8.11
JAK3	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	4.53
JAK2	Janus kinase 2 (a protein tyrosine kinase)	4.41
ISG15	ISG15 ubiquitin-like modifier	4.29
STAT1	Signal transducer and activator of transcription 1, 91kDa	4.00
FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)	3.86
STAT5A	Signal transducer and activator of transcription 5A	3.27
CDKN1A	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	2.55
MMP3	Matrix metallopeptidase 3 (stromelysin 1, progelatinase)	2.51
OSA1	2′,5′-oligoadenylate synthetase 1, 40/46kDa	2.50
IL10 RA	Interleukin 10 receptor, alpha	2.33
ISGF3G	Interferon-stimulated transcription factor 3, gamma 48kDa	2.27
OSM	Oncostatin M	2.27
STAT2	Signal transducer and activator of transcription 2, 113kDa	2.20
JUN	Jun oncogene	2.17
SH2B2	SH2B adaptor protein 2	2.07
JUNB	Jun B proto-oncogene	2.04