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. Author manuscript; available in PMC: 2010 May 1.

Published in final edited form as: Gastroenterology. 2009 Jan 25;136(5):1552–1560. doi: 10.1053/j.gastro.2009.01.048

Hepatic insulin sensitivity index (HISI) (top panel) in subjects consuming ether a high-carbohydrate or low-carbohydrate diet and changes in insulin mediated glucose uptake, an index of skeletal muscle insulin sensitivity, in both groups combined (bottom panel) after 48 h and ~11 wks (7% weight loss) of calorie restriction. Value significantly different from baseline value: * P<0.05, ** P<0.001. Value significantly different from value in HC group, ^# P<0.05.

Hepatic insulin sensitivity index (HISI) (top panel) in subjects consuming ether a high-carbohydrate or low-carbohydrate diet and changes in insulin mediated glucose uptake, an index of skeletal muscle insulin sensitivity, in both groups combined (bottom panel) after 48 h and ~11 wks (7% weight loss) of calorie restriction. Value significantly different from baseline value: * P<0.05, ** P<0.001. Value significantly different from value in HC group, ^# P<0.05.