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. Author manuscript; available in PMC: 2009 Nov 5.

Published in final edited form as: J Am Chem Soc. 2008 Oct 9;130(44):14675–14683. doi: 10.1021/ja804656h

Two time points in the D₂O exchange (pD = 3.84) of a mixture of Pr-WIpGLWTGPS and its unfolded p3P mutant: A, 1.16 h; B, 15.6 h. Resonances of the unfolded control are labeled below the trace in panel A; labels above the trace are for the folded peptide; “x” denotes the location of resonances due to the cis-Gp amide species which is also folded. The Gly8 H_N appearing at 4.57 ppm, not on the spectral segment shown here (see Supporting Information), is protected to comparable degree.

Two time points in the D₂O exchange (pD = 3.84) of a mixture of Pr-WIpGLWTGPS and its unfolded p3P mutant: A, 1.16 h; B, 15.6 h. Resonances of the unfolded control are labeled below the trace in panel A; labels above the trace are for the folded peptide; “x” denotes the location of resonances due to the cis-Gp amide species which is also folded. The Gly8 H_N appearing at 4.57 ppm, not on the spectral segment shown here (see Supporting Information), is protected to comparable degree.