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. 2009 May 19;3(5):e438. doi: 10.1371/journal.pntd.0000438

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Each symbol represents individual samples from the 38 Ov-infected, 90 Wb, 90 Ll, 27 Ss, 72 control uninfected samples and 12 other control patients. These LIPS tests were either evaluated as a mixture in the standard format (A) or with QLIPS (B). As shown, both tests showed 100% sensitivity and 100% specificity in distinguishing the uninfected from the Ov-infected sera. The diagnostic performance related to cross-reactivity with other filarial infections was also evaluated. As described in the text, the long solid line represents the cut-off level corresponding to 100% sensitivity, while the long stippled line corresponds to the cut-off for 100% specificity with sera from the Wb cohort.