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. Author manuscript; available in PMC: 2009 May 5.

Published in final edited form as: Angiogenesis. 2008 May 27;11(3):301–310. doi: 10.1007/s10456-008-9113-5

To analyze the role of LPA receptors in LPA-induced angiogenesis we used the LPA₁ and LPA₃ receptor antagonist, VPC32183. Using the same approach aforementioned, we show in 3A and 3B that LPA-induced angiogenesis is blocked completely by this compound at 10µM. Importantly, VPC32183 alone (at 10µM) had no discernable effect in angiogenesis and does not block VEGF-induced angiogenesis (Figure 3C). One-Way ANOVA test was performed between groups. ** P< 0.001. Error bars represent standard deviation (SD). In figure 3B (scale bar: 0.125 cm), we present the image of a single membrane representative of each group.

To analyze the role of LPA receptors in LPA-induced angiogenesis we used the LPA₁ and LPA₃ receptor antagonist, VPC32183. Using the same approach aforementioned, we show in 3A and 3B that LPA-induced angiogenesis is blocked completely by this compound at 10µM. Importantly, VPC32183 alone (at 10µM) had no discernable effect in angiogenesis and does not block VEGF-induced angiogenesis (Figure 3C). One-Way ANOVA test was performed between groups. ** P< 0.001. Error bars represent standard deviation (SD). In figure 3B (scale bar: 0.125 cm), we present the image of a single membrane representative of each group.