Fig 5.

Double-labeling for phospho-tau (A and D) (green) and TDP-43 (B and E) (red) with merged images (C and F) shows two types of co-localization of phospho-tau and TDP-43. In Type 1 (D, E and F) there is overlap of the epitopes in some of the inclusions, while other inclusions are single labeled for either tau or TDP-43. In Type 2 (A, B and C) there is intermingling, but separation, of the two epitopes within the same neuron, as well as inclusions that are single labeled for either tau or TDP-43. All images are ×400.