Table 3.
Demographics and Pathology of Cases with TDP-43 Immunoreactivity
| Initial series |
Confirmation series | ||||
|---|---|---|---|---|---|
| HpScl/pure (n=8) | HpScl/other (n=5) | HpScl/AD (n=33) | AD (n=9) | AD (n=19) | |
| Age at death, mean ± SD (y) | 87 ± 4 | 84 ± 6 | 86 ± 6 | 84 ± 4 | 82 ± 7 |
| Sex, M:F | 5:3 | 3:2 | 17:16 | 3:6 | 9:10 |
| Braak stage, median (25%-tile, 75%-tile) | 2.2 (1.5, 2.8) | 2.5 (2, 3) | 5 (4.5, 6) | 6 (5, 6) | 5.5 (5, 6) |
| Brain weight, mean ± SD (g) |
1130 ± 220 |
1110 ± 82 |
1020 ± 140 |
1040 ± 74 |
990 ± 130 |
| Other pathology (number of cases) | |||||
| Hippocampal sclerosis | 8 | 5 | 33 | 0 | 0 |
| Alzheimer's disease | 0 | 0 | 33 | 9 | 19 |
| Cerebrovascular disease | 4 | 0 | 12 | 2 | 7 |
| Argyrophilic grains | 2 | 3 | 1 | 0 | 0 |
| Lewy bodies | 0 | 4 | 9 | 4 | 5 |
| Multiple system atrophy | 0 | 1 | 0 | 0 | 0 |