Table 3.

Catecholamine, prolactin, and corticosterone concentrations in L. monocytogenes- or sham-infected mice

	Genotype	Numbers	NE	EP	Dopamine	Prolactin	Corticosterone
Primary infection	+/−	5	6.0  ±  0.6	10.8  ±  1.6	0.7  ±  0.1	4.0  ±  0.4	86.3  ±  19.7
	−/−	4	<0.1	0.7  ±  0.2	9.7  ±  3.6	2.9  ±  0.5	366.7  ±  101.2†
Primary sham	+/−	5	5.3  ±  0.5	7.9  ±  1.1	0.9  ±  0.2	5.0  ±  1.0	49.2  ±  18.0
	−/−	5	<0.1	1.0  ±  0.2	12.0  ±  1.7	7.1  ±  1.0	114.2  ±  26.9‡
Secondary infection	+/−	5	2.9 ± 0.3	4.8  ±  0.5	0.4  ±  0.1	nd	54.4  ±  13.1
	−/−	3	<0.1	0.3  ±  0.2	4.5  ±  2.0	nd	68.4  ±  57.8
Secondary sham	+/−	5	3.7 ± 0.4	4.4  ±  0.7	0.8  ±  0.1	nd	116.9  ±  23.9
	−/−	5	<0.1	0.6  ±  0.2	7.6  ±  2.0	nd	77.0  ±  28.4

Mice were infected i.p. with L. monocytogenes or sham-infected (i.p. saline) as described in Fig. 2. Plasma was collected day 5 postprimary and day 3 postsecondary infection. Values are the mean ± SEM (ng/ml). We have not previously detected EP in dbh^−/− mice using HPLC and electrochemical detection (2), suggesting that the current values for EP in dbh^−/− mice reflect cross-reactivity of dopamine in the RIA used in the current studies. nd, not done. 

^†P = 0.02,  

^‡P = 0.08, by two-tailed Student’s t test. Other comparisons for corticosterone and prolactin concentrations, P > 0.1. All catecholamine values differed significantly between dbh^−/− and dbh^+/− mice (P < 0.01).