TABLE 5.
COMPARISON OF PROPORTION OF FATAL INFECTIONS AND INTENSITY AND TYPE OF TREATMENT
| No. Patients | No. Fatal Infections | Proportion of Fatal Infections (95% CI) | P Value | ||
|---|---|---|---|---|---|
| Phase 1 | Standard | 335 | 3 | 0.9% (0.3, 2.4%) | 0.004 |
| Intensive | 343 | 19 | 5.5% (3.5, 8.3%) | ||
| Phase 2* | Chemo Course 1 | 168 | 4 | 2.4% (0.8, 5.6%) | 0.5361, 0.5052 |
| Standard | 65 | 1 | 1.5% (0.1, 7.4%) | 0.5773 | |
| Intensive | 103 | 3 | 2.9% (0.8, 7.6%) | ||
| Autologous SCT | 137 | 5 | 3.6% (1.4, 7.8%) | 0.2284 | |
| Standard | 44 | 2 | 4.5% (0.8, 13.7%) | 0.677 | |
| Intensive | 93 | 3 | 3.2% (0.9, 8.4%) | ||
| Allogeneic SCT | 147 | 2 | 1.4% (0.3, 4.4%) | ||
| Standard | 52 | 1 | 1.9% (0.2, 9.0%) | 0.655 | |
| Intensive | 95 | 1 | 1.1% (0.1, 5.2%) |
1
chemotherapy vs. autologous
2
chemotherapy vs. allogeneic
3
standard vs. intensive (Phase 2 fatal infections by induction)
4
autologous vs. allogeneic
*
Phase 2 therapy mortality also shown according to whether patient was randomized to standard versus intensive timing in induction
Abbreviations: CI - confidence interval; SCT - stem cell transplantation; No - number