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. 2009 May 1;6(3):249–255. doi: 10.1513/pats.200806-054RM

Figure 4.

Figure 4.

Overview of activation of the canonical (classical) NF-κB pathway, and visualization of the inhibitory effect of cysteine oxidation of IKKβ at cysteine 179 on activation of the NF-κB pathway. We have also highlighted that the same cysteine is targeted by the antiinfammatory prostaglandins, PGA1 and 15dPGJ2. 15dPGJ2 = 15-deoxy-Δ12–14-prostaglandin J2; PGA1 = prostaglandin A1; SNO = S-nitrosylation; SSG = S-glutathionylation. Inhibition of RelA and p50 after S-nitrosylation and S-glutathionylation is also highlighted.