Figure 1.

Specific lysis shown by three selected CTL clones generated from an HLA-B8⁺, healthy virus carrier SP after stimulation in vitro of PBMCs with the autologous LCL. Clones were tested in standard 4-h ⁵¹Cr-release assays against autologous PHA blasts pulsed with the BZLF1-associated RAK peptide or peptide homologues derived from known human pathogens or putative autoantigens, as listed on the ordinate. Amino acid positions in the protein sequence are given in parentheses. Triple peptide-reactive clone SP42 (□), double peptide-reactive clone SP35 (■), and single peptide-reactive clone SP28 (▧). Effector/target ratio, 2:1.