TABLE 2.
ADHESION MOLECULE INVOLVED IN NEUTROPHILS TRANSEPITHELIAL AND TRANSENDOTHELIAL MIGRATION
| Endothelium | Intestinal Epithelium | Bronchial Epithelium | Alveolar Epithelium | |
|---|---|---|---|---|
| CD18/CD11a (LFA-1) | + | — | + | + |
| CD18/CD11b (Mac-1) | + | + | + | + |
| CD18/CD11c (p150) | + | — | + | ? |
| CD18/CD11d | — | — | — | ? |
| CD18-Independent | + | +/− | + | + |
| ICAM-1 (CD54) | + | — | +/− | — |
| PECAM (CD31) | + | — | — | — |
| CD62L, E, P (Selectins) | + | — | — | — |
| Carbohydrates | + | + | ? | ? |
| JAM-A | + | — | ? | ? |
| JAM-C | + | + | ? | + |
| JAML | + | + | ? | ? |
| CAR | — | + | ? | ? |
| CD47 | + | + | ? | ? |
Definition of abbreviations: CAR, coxsackie and adenovirus receptor; ICAM, intercellular adhesion molecule; JAM, junctional adhesion molecule; PECAM, platelet endothelial cell adhesion molecule.
Although there are many similarities, distinct adhesion molecules are often involved in neutrophil migration across the endothelium and epithelium. Moreover, neutrophil migration across intestinal, bronchial, and alveolar epithelium may be mediated by distinct adhesion molecules.