TABLE 2.
BIOMETRY AND LUNG MORPHOMETRY OF ANIMALS RE-EXPOSED TO HYPEROXIA
| 10 wk
|
||
|---|---|---|
| Post-TPX interval:
|
P66
|
P78
|
| Age | Hyperoxia × 1 | Hyperoxia × 2 |
| TPX (5) | TPX (6) | |
| Body weight, g | 18.18 ± 0.59 | 20.81 ± 1.39 |
| V(lu), μl | 334.0 ± 22.2 | 379.3 ± 34.8 |
| AA(ae/lu), % | 31.3 ± 1.64 | 33.6 ± 0.88* |
| V(ae), μl | 105.2 ± 11.1 | 126.5 ± 9.2† |
| V(ae)/body weight, μl/g | 5.78 ± 0.56 | 6.64 ± 0.59 |
| AA(gfp/ae), % | 1.54 ± 0.43 | 2.26 ± 0.42 |
| V(gfp), μl | 1.68 ± 0.51 | 2.78 ± 0.41† |
| Ki-67 labeling index, #/HPF | 12.28 ± 2.49 | 16.56 ± 2.97* |
Definition of abbreviations: AA(ae/lu), areal fraction of air-exchanging parenchyma relative to lung parenchyma; AA(gfp/ae), areal fraction of GFP-immunoreactive parenchyma relative to air-exchanging parenchyma; HPF, high-power field; post-TPX interval, number of weeks between marrow cell transplantation (P5) and killing; TPX: marrow cell-transplanted; V(ae), volume of air-exchanging parenchyma; V(gfp), volume of GFP-immunoreactive cells; V(lu), inflated lung volume.
Values represent mean ± SEM of (n) animals per group. Hyperoxia × 1: marrow-treated animals exposed to hyperoxia as newborns only (P1-P7). Hyperoxia × 2: marrow-treated animals exposed to hyperoxia as newborns (P1-P7) and reexposed to hyperoxia at P66 (P66-P68).
P < 0.05 versus hyperoxia × 1 group.
P < 0.02 versus hyperoxia × 1 group.