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. 2009 May 13;4(5):e5530. doi: 10.1371/journal.pone.0005530

Figure 4. Metabolites of hippocampal neurons reduced Aβ-degrading enzymes expression and caused cerebellar neurodegeneration in APP/PS1 transgenic mice.

Figure 4

(A) Western blot analysis of NEP and IDE expression in cerebellar neurons treated with conditioned medium. (B) The Aβ1-40 ELISA result shows that H-CM induced cerebellar Aβ levels compared with C-CM. (C) Injection of CSF from the lateral ventricle (LV) induced cerebellar Aβ levels compared with CSF from the fourth ventricle (4V) (*P<0.05, ** P<0.01). (D) Motor function of APP/PS1 mice treated with H-CM was impaired in a pole test and (E) balance beam test (n = 6 to 11).