Figure 2 Changes within markers of neuronal metabolism found during both early and chronic HIV infection

N-acetylaspartate (NAA) (A) and glutamate + glutamine (Glx) (B) levels in the frontal cortical gray matter are reduced in subjects during the first few months of infection, similar to subjects with chronic infection who are neurologically asymptomatic. Within the white matter of the centrum semiovale, NAA (C) was found to be reduced in those infected and on treatment for many years with HIV, but not in those during early infection. No changes from control levels for Glx in the white matter were observed (D).