Figure 2 Humoral immune parameters in CSF

Oligoclonal bands (OCBs) were assessed in all patient samples. Two examples of the OCBs detection assay are shown (A). The number of OCBs (B), the amount of IgG synthesis (D), and the CSF/serum albumin quotient (E) did not differ between patients on natalizumab [MS (Nat)] and 6 months (MS Nat 6 months) or 14 months (MS Nat 14 months) after cessation of the drug. The total amount of intrathecal IgG increased significantly 6 months after cessation of natalizumab, and remained stable over the next 8 months (C).