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. Author manuscript; available in PMC: 2009 May 5.
Published in final edited form as: Neuromolecular Med. 2009 Mar 14;11(1):28–42. doi: 10.1007/s12017-009-8058-1

Fig. 4.

Fig. 4

Evidence that SIRT1 activity contributes to excitotoxic neuronal death. a SIRT1 deacetylase activities in cell extracts of neurons that had been exposed to the indicated concentrations of resveratrol or nicotinamide for 2 h. b Immunoblot showing SIRT1 levels in cortical neurons that had been treated for 2 h with the indicated concentrations of nicotinamide and sirtinol. c-e Survival of cortical neurons in cultures that had been treated with the indicated concentrations of sirtinol, NAD, NADH, or resveratrol, and then exposed to glutamate/NMDA for 24 h. f NAD+ levels in cortical neurons that had been treated with indicated concentration of resveratrol for 24 h. Values are the mean and SD of determinations made in at least four separate cultures. *P< 0.05, **P < 0.01