Figure 4. KEGG categories enriched or depleted in the core versus variable components of the gut microbiome.
Sequences from each of the 18 fecal microbiomes were binned into the ‘core’ or ‘variable’ microbiome based on the co-occurrence of KEGG orthologous groups (core groups were found in all 18 microbiomes while variable groups were present in fewer (<18) microbiomes; see Supplementary Figure 19A). Asterisks indicate significant differences (Student’s t-test, *p<0.05, **p<0.001, ***p<10−5; mean±SEM).