Table 1.
Group Characteristics
| BAC NC | UCSF AD | ADNI NC | ADNI PIB− MCI | ADNI PIB+ MCI | ADNI AD | |
|---|---|---|---|---|---|---|
| N | 20 | 20 | 17 | 13 | 39 | 15 |
| Age | 72.3 (6.0) | 64.3 (8.8)** | 78.5 (5.4) | 72.7 (7.8)* | 75.0 (7.9) | 72.6 (8.7)* |
| Gender | 13F, 7M | 9F, 11M | 7F, 10M | 3F, 10M | 13F, 26M | 5F, 10M |
| Education | 18.3 (2.8) | 16.7 (3.1) | 14.9 (3.2) | 16.8 (2.6) | 16.2 (2.9) | 14.9 (2.7) |
| MMSE | 29.6 (0.6) | 19.7 (6.7)*** | 28.6 (1.5) | 27.1 (2.8) | 27.4 (2.0)* | 22.7 (2.9)*** |
| PIB Index | SUVR: 1.40 (0.09); | SUVR: 2.02 (0.41)*** | SUVR: 1.64 (0.49) | SUVR: 1.30 (0.10)* | SUVR: 2.14 (0.44)** | SUVR: 2.18 (0.45)** |
| DVR: 1.44 (0.10) | DVR: 2.13 (0.33)*** | |||||
| Episodic Memory | −0.05 (0.85) | NAa | 0.00 (1.0) | −1.29 (0.79)*** | −1.11 (1.14)*** | −1.89 (0.29)*** |
a
Episodic memory scores were assessed with the CVLT 9 item variant in UCSF AD. Values are listed as mean (SD). In statistical contrasts, UCSF AD are compared to BAC NC; for ADNI groups, MCI and AD are compared to NC (*P < 0.05, **P < 0.01, ***P < 0.001). For BAC NC and UCSF AD, PIB index values were computed using both DVR and SUVR approaches (DVR values were used for regression analyses, whereas SUVR values were used for comparison with ADNI values).