Table 1.
Subject demographics
| Characteristics | Cognitively normal |
Amnestic mild cognitive impairment |
Alzheimer's disease |
|||
|---|---|---|---|---|---|---|
| ADNI | Mayo | ADNI | Mayo | ADNI | Mayo | |
| Number of subjects | 11 | 10 | 23 | 9 | 4 | 4 |
| Age at first PIB exam, median (range), years | 72 (63–87) | 75 (72–90) | 75 (61–88) | 79 (72–87) | 70 (68–77) | 66 (54–80) |
| Gender, no. (%) male | 8 (73) | 7 (70) | 14 (61) | 5 (56) | 3 (75) | 1 (25) |
| Education, median (range), years | 14 (12–20) | 16 (12–20) | 16 (12–20) | 12 (12–19) | 16 (12–20) | 16 (13–20) |
| APOE, no. (%) e4 carriera | 2 (18) | 3 (30) | 14 (61) | 2 (33) | 1 (25) | 1 (100) |
| MMSE, median (range) | 29 (24–30) | 28 (25–30) | 27 (24–30) | 27 (24–28) | 24 (20–24) | 22 (17–26) |
| CDR–SB, median (range)a | 0 (0–1) | 0 (0–0.5) | 1.5 (0.5–4) | 1.5 (0–3) | 5 (4–6) | 4 (1.5–6) |
| Months between PIB exams, median (range) | 12 (11–13) | 14 (14–17) | 12 (9–14) | 14 (12–23) | 12 (9–12) | 12 (9–25) |
| Months between MRI exams, median (range) | 12 (11–13) | 15 (13–17) | 13 (11–15) | 15 (14–23) | 12 (11–12) | 12 (12–28) |
| Diagnosis at second PIB exam, no. (%)a | ||||||
| Cognitively normal | 10 (100) | 9 (90) | 1 (5) | 1 (11) | 0 | 0 |
| MCI | 0 | 1 (10) | 14 (70) | 5 (56) | 0 | 0 |
| Alzheimer's disease | 0 | 0 | 5 (25) | 3 (33) | 4 (100) | 4 (100) |
a Missing data: three Mayo amnestic MCI and three Mayo AD subjects missing APOE e4 status; one ADNI CN missing CDR-SB; one ADNI CN and three ADNI amnestic MCI subjects missing diagnosis at second PIB exam.