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. 2009 Mar 31;132(5):1175–1189. doi: 10.1093/brain/awp070

Figure 3.

Figure 3

(A and B) Graphs show examples of the interdependence of inflammation and neurodegeneration among progressive multiple sclerosis patients (SPMS and PPMS). Multiple sclerosis values represent lesional mean values for all lesion types per patient. We observe highly significant positive correlations between acute axonal injuries and inflammatory infiltrates (A and B) among progressive multiple sclerosis patients. We also find those correlations when analysed in all multiple sclerosis cases (acute–relapsing, SPMS and PPMS) (see Results section). (C and D) Graphs express examples of the relation between age and densities of inflammatory infiltrates (C) or axonal injury (D) in progressive multiple sclerosis (SPMS and PPMS) lesions. Multiple sclerosis values represent lesional values for all lesion types per patient. We find highly significant negative correlations between inflammation and age at death (C) and age at death and axonal injury (D) among progressive multiple sclerosis patients. Those negative correlations also persist when analysed in all multiple sclerosis patients (see Results section). For more detailed information see Supplementary Table 2.