Figure 4.

Coronal sections through the hippocampal brain region of T. b. brucei-infected mice exhibiting the early CNS stage of the disease. The animals were treated with Ro-61-8048 (100 mg/kg i.p.) (A) untreated animals (B) or vehicle only (C). Uninfected mice treated with Ro-61-8048 (D) are included as a control. All treatments were administered every second day beginning on Day 12 post-infection until the end point of the experiment on Day 28 post-infection. Note the presence of mild inflammation in sections A–C with a few inflammatory cells present around the blood vessels. No inflammatory changes are apparent in the uninfected animals (D).