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Relationship between the PDE8A1 concentration and cAMP conversion. The assays were carried out at a protein concentration range of 5.3 to 84.8 ng/ml and in a buffer of 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, 1 mM DTT, 3H-cAMP (20000 cpm/assay) at 24°C for 15 min.