Table 1.
Frequency of formation of different hydrogen bonds between Pt-amines and adjacent bases
| TGGA | |||
|---|---|---|---|
| CP |
OXa |
||
| Hydrogen bond type | Frequency (%) | Hydrogen bond type | Frequency (%) |
| G7-O6 | 32 | G7-O6 | 55 |
| A8-N7 | 13 | T17-O4 | 15 |
| T5-O3′ | 6 | ||
| None | 54 | None | 23 |
| AGGCb | |||
| CP |
OXc |
||
| Hydrogen bond type | Frequency (%) | Hydrogen bond type | Frequency (%) |
| G7-O6 | 13 | G7-O6 | 34 |
| A5-N7 | 40 | A5-N7 | 14 |
| A5-N7 + G7-O6 | 34 | A5-N7 + G7-O6 | 45 |
| None | 13 | None | 8 |
aOnly the equatorial hydrogen of the OX-amine was involved in hydrogen bonding on the 3′ side of the adduct.
bFrom ref. 26.
cBoth equatorial and axial hydrogens of the OX-amine were involved in hydrogen bonds on the 5′ side, and only equatorial hydrogen of the OX-amine was involved in hydrogen bonding on the 3′ side of the adduct.