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Proposed interaction between mtDNA repair and degradation pathways. Glycosylase I and Glycosylase II, mono- and bi-functional DNA glycosylases. A bi-functional DNA glycosylase also posseses an AP-lyase activity (makes an incision at an abasic site). APE, apurinic/apyrimidinic endonuclease APE/Ref1. See ‘Discussion’ section for details.
