Table 10.
Activity (EC50) and Cytotoxicity (CC50) for Wild-Type and Variant Strains of HIV-1a
| WT |
Y181C |
K103N/Y181C |
||||
|---|---|---|---|---|---|---|
| compd | EC50 (µM) | CC50 (µM) | EC50 (µM) | CC50 (µM) | EC50 (µM) | CC50 (µM) |
| 13 | 0.13 | 40 | 21 | 72 | 24 | >100 |
| 27 | 0.11 | 2.8 | NA | 6 | NA | 15 |
| 28 | 0.022 | 2.1 | NA | 4 | NA | 5 |
| 29 | 0.013 | 7.4 | NA | 8 | ND | ND |
| d4T | 1.4 | >100 | 0.68 | >100 | 0.28 | >100 |
| efavirenz | 0.002 | >0.1 | 0.013 | >0.1 | 0.050 | >0.1 |
| TMC125 | 0.001 | >0.1 | 0.014 | ND | 0.005 | ND |
See footnotes in Table 4. NA for EC50 > CC50; ND = not determined.