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. Author manuscript; available in PMC: 2009 May 6.
Published in final edited form as: J Am Chem Soc. 2008 Jun 28;130(29):9492–9499. doi: 10.1021/ja8019214

Table 10.

Activity (EC50) and Cytotoxicity (CC50) for Wild-Type and Variant Strains of HIV-1a

WT
 Y181C
 K103N/Y181C
compd EC50 (µM) CC50 (µM) EC50 (µM) CC50 (µM) EC50 (µM) CC50 (µM)
13 0.13 40 21 72 24 >100
27 0.11 2.8 NA 6 NA 15
28 0.022 2.1 NA 4 NA 5
29 0.013 7.4 NA 8 ND ND
d4T 1.4 >100 0.68 >100 0.28 >100
efavirenz 0.002 >0.1 0.013 >0.1 0.050 >0.1
TMC125 0.001 >0.1 0.014 ND 0.005 ND
a

See footnotes in Table 4. NA for EC50 > CC50; ND = not determined.