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. Author manuscript; available in PMC: 2009 May 6.
Published in final edited form as: J Am Chem Soc. 2008 Jun 28;130(29):9492–9499. doi: 10.1021/ja8019214

Table 9.

Heterocycle Analogues: Anti-HIV-1 Activity (EC50) and Cytotoxicity (CC50)

graphic file with name nihms88205t8.jpg
compd R R′ R″ W Y EC50a(µM) CC50a(µM)
21 Cl Cl H S N NA >100
22 Cl Cl H S CH 3.1 29
23 Cl Cl Cl S CH 1.4 9.8
24 Cl CN H S CH 0.43 >100
25 Cl Et H O CH 2.8 >100
26 Cl F H O CH 0.43 12
27 Cl Cl H O CH 0.11 2.8
28 Cl CN H O CH 0.022 2.1
29 F CN H O CH 0.013 7.4
a

See footnotes in Table 4. NA for EC50> CC50.