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Front and side view of the region containing R56 and R88 of bovine erythrocytes carbonic anhydrase II (PDB ID: 1V9E)[72]. The line of sight between the target side-chains is obstructed by the loop comprised between Y69 and V77. The formation of R56-R88 crosslinks can take place only if the susceptible arginines and intervening loop are capable of adopting alternative conformations in solution.
