Table 5.
Risk of Mortality Due to Subsequent Malignancy, Cardiac Disease, and Other Causes
| Independent Risk Factor | Subsequent Malignancy |
Cardiac |
Other Causes |
|||
|---|---|---|---|---|---|---|
| RR | 95% CI | RR | 95% CI | RR | 95% CI | |
| Sex | ||||||
| Male | 1.0 | 1.0 | 1.0 | |||
| Female | 1.3 | 1.1 to 1.5* | 1.4 | 1.0 to 1.9† | 1.9 | 1.5 to 2.4* |
| Age at diagnosis, years | ||||||
| 0-4 | 1.5 | 1.1 to 1.9* | 2.1 | 1.3 to 3.6* | 1.3 | 0.9 to 1.9 |
| 5-9 | 1.1 | 0.8 to 1.4 | 1.4 | 0.9 to 2.3 | 1.5 | 1.1 to 2.2† |
| 10-14 | 0.9 | 0.7 to 1.2 | 0.8 | 0.5 to 1.3 | 1.1 | 0.8 to 1.6 |
| 15-20 | 1.0 | 1.0 | 1.0 | |||
| Years of diagnosis | ||||||
| 1970-1973 | 1.3 | 1.0 to 1.8 | 1.7 | 0.9 to 3.4 | 1.2 | 0.7 to 1.8 |
| 1974-1977 | 1.1 | 0.8 to 1.4 | 2.1 | 1.2 to 3.7† | 0.9 | 0.6 to 1.3 |
| 1978-1981 | 0.8 | 0.6 to 1.1 | 1.8 | 1.0 to 3.1 | 0.8 | 0.5 to 1.2 |
| 1982-1986 | 1.0 | 1.0 | 1.0 | |||
| Years since diagnosis | ||||||
| 5-9 | 2.7 | 2.1 to 3.5* | 2.2 | 1.3 to 3.6* | 1.6 | 1.1 to 2.3† |
| 10-14 | 1.9 | 1.5 to 2.5* | 1.7 | 1.0 to 2.7† | 1.4 | 1.0 to 2.0 |
| 15-19 | 1.4 | 1.1 to 1.8† | 1.5 | 1.0 to 2.3† | 0.9 | 0.6 to 1.3 |
| 20+ | 1.0 | 1.0 | 1.0 | |||
| Radiation‡ | ||||||
| Yes | 2.9 | 2.1 to 4.2* | 3.3 | 2.0 to 5.5* | 2.0 | 1.3 to 3.1* |
| No | 1.0 | 1.0 | 1.0 | |||
| Alkylating agent score | ||||||
| Not exposed | 1.0 | 1.0 | 1.0 | |||
| 1-2 | 1.4 | 1.0 to 2.0† | 0.6 | 0.3 to 1.2 | 1.0 | 0.7 to 1.7 |
| 3-4 | 1.8 | 1.1 to 2.8† | 0.6 | 0.3 to 1.4 | 1.2 | 0.8 to 1.9 |
| 5+ | 2.2 | 1.6 to 3.0* | 1.7 | 1.0 to 3.0 | 1.7 | 1.0 to 2.9† |
| Anthracycline, mg/m2 | ||||||
| Not exposed | 1.0 | 1.0 | 1.0 | |||
| 1-100 | 1.1 | 0.5 to 2.1 | 2.5 | 0.7 to 9.2 | 1.7 | 0.7 to 4.1 |
| 101-250 | 1.1 | 0.6 to 1.9 | 2.3 | 0.9 to 6.0 | 1.6 | 0.9 to 3.1 |
| 251-400 | 1.2 | 0.8 to 1.7 | 2.2 | 1.3 to 4.0* | 1.4 | 0.9 to 2.2 |
| 401+ | 1.4 | 0.9 to 2.1 | 3.1 | 1.6 to 5.8* | 1.7 | 0.9 to 3.0 |
| Epipodophyllotoxin, mg/m2 | ||||||
| Not exposed | 1.0 | 1.0 | 1.0 | |||
| 1-982 | 1.1 | 0.4 to 2.7 | 0.7 | 0.1 to 5.1 | 1.2 | 0.3 to 4.5 |
| 983-4,108 | 1.6 | 0.6 to 4.0 | 0.8 | 0.1 to 6.0 | 0.9 | 0.2 to 3.8 |
| 4,109+ | 2.3 | 1.2 to 4.5† | 1.9 | 0.4 to 8.5 | 0.8 | 0.2 to 3.9 |
| Bleomycin, mg/m2 | ||||||
| Not exposed | 1.0 | 1.0 | 1.0 | |||
| 1-59 | 1.2 | 0.7 to 2.1 | 1.7 | 0.8 to 3.9 | 0.8 | 0.3 to 2.3 |
| 60-119 | 1.2 | 0.5 to 2.7 | 0.9 | 0.3 to 2.8 | 1.0 | 0.3 to 3.0 |
| 119+ | 1.9 | 0.8 to 4.5 | 1.3 | 0.3 to 5.7 | 0.6 | 0.1 to 3.3 |
NOTE. Other causes include deaths not due to recurrence, subsequent malignancy, cardiac, pulmonary or external causes.
Abbreviation: RR, relative risk.
*
P < .01.
†
P < .05.
‡
Radiation is overall radiation for subsequent malignancy; chest/spine/total-body irradiation for cardiac; chest/total-body irradiation for pulmonary.