Table 5.
Incidence Rates and Relative Risks by Time Period of Onset of Adverse Neurologic Outcomes109
| Parameter | Neurosensory Deficits |
Focal Neurologic Dysfunction |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Any Hearing Impairment | Tinnitus | Persistent Dizziness | Legal Blindness in One or Both Eyes | Cataracts | Problems With Double Vision | Any Coordination Problem | Any Motor Problem | Any Seizure Disorder | |
| Reported outcome | |||||||||
| Yes* | |||||||||
| No. | 192 | 171 | 155 | 211 | 48 | 278 | 784 | 425 | 401 |
| % | 12 | 11 | 10 | 13 | 3 | 17 | 49 | 26 | 25 |
| No† | |||||||||
| No. | 1,402 | 1,422 | 1,439 | 1,384 | 1,557 | 1,315 | 757 | 1,159 | 1,114 |
| % | 87 | 88 | 90 | 86 | 97 | 82 | 47 | 72 | 69 |
| Diagnosis to end of treatment, yes | |||||||||
| No. of patients | 46 | 45 | 76 | 92 | 6 | 130 | 408 | 196 | 141 |
| Rate‡ | 16.6 | 15.9 | 25.5 | 32.8 | 2.0 | 43.7 | 189.4 | 79.7 | 54.4 |
| 95% CI | 12.4 to 22.1 | 11.8 to 21.4 | 20.2 to 32.2 | 26.5 to 40.5 | 0.9 to 4.5 | 36.4 to 52.5 | 170.7 to 210.2 | 69.3 to 91.6 | 45.9 to 64.5 |
| RR§‖ | 42.8 | 17.2 | 44.9 | 93.2 | 9.8 | 123.5 | 158.8 | 121.4 | 55.3 |
| 95% CI | 27.1 to 67.5 | 11.8 to 25.0 | 32.1 to 62.9 | 59.8 to 145.4 | 3.9 to 24.6 | 83.6 to 182.3 | 127.2 to 198.4 | 92.7 to 159.0 | 41.5 to 73.6 |
| End of treatment to 5 years after diagnosis, yes | |||||||||
| No. of patients | 58 | 33 | 26 | 77 | 11 | 73 | 189 | 94 | 101 |
| Rate‡ | 9.4 | 7.2 | 6.2 | 14.8 | 2.2 | 17.1 | 67.0 | 21.6 | 23.1 |
| 95% CI | 7.3 to 12.1 | 5.2 to 9.8 | 4.6 to 8.5 | 12.0 to 18.3 | 1.2 to 3.8 | 13.9 to 20.9 | 59.4 to 75.6 | 18.1 to 25.9 | 19.3 to 27.6 |
| RR§‖ | 26.7 | 7.0 | 9.6 | 55.1 | 11.2 | 43.5 | 60.2 | 35.8 | 24.7 |
| 95% CI | 17.4 to 40.9 | 4.8 to 10.2 | 6.4 to 14.3 | 34.6 to 87.8 | 5.4 to 23.4 | 29.2 to 64.9 | 47.8 to 75.9 | 26.6 to 48.3 | 18.5 to 33.1 |
| 5 years after diagnosis to end of follow-up, yes | |||||||||
| No. of patients | 76 | 59 | 35 | 19 | 22 | 41 | 74 | 85 | 105 |
| Rate‡ | 5.9 | 5.4 | 2.9 | 1.9 | 1.7 | 3.9 | 11.8 | 7.6 | 10.3 |
| 95% CI | 4.8 to 7.4 | 4.3 to 6.9 | 2.1 to 4.0 | 1.3 to 2.8 | 1.1 to 2.5 | 3.0 to 5.3 | 9.5 to 14.7 | 6.1 to 9.3 | 8.5 to 12.4 |
| RR§‖ | 17.3 | 3.7 | 3.2 | 14.8 | 11.9 | 8.8 | 12.6 | 12.4 | 12.6 |
| 95% CI | 11.6 to 25.8 | 2.7 to 5.1 | 2.2 to 4.8 | 7.5 to 29.2 | 5.7 to 24.8 | 5.6 to 13.8 | 9.1 to 17.5 | 8.7 to 17.5 | 9.2 to 17.1 |
Abbreviation: RR, relative risk.
*
Excludes conditions prior to diagnosis.
†
Includes ″not sure″ and missing responses.
‡
Rate per 1,000 person-years.
§
Adjusted for sex; relative to siblings.
‖
P < .0001.