Table 3.

Host and Treatment Factors Increasing Risk of Selected Subsequent Neoplasms After Childhood Cancer

Subsequent Cancer	Host Factor	Treatment Factor
Any subsequent malignancy histology41	Female sex, young age at diagnosis; primary diagnosis Hodgkin's disease or soft tissue sarcoma	Alkylating agents; epipodophyllotoxins; anthracyclines
Breast39	Female sex; primary diagnosis of bone tumor or soft tissue sarcoma	Chest radiation
Thyroid8,45	Younger age at diagnosis	Thyroid radiation (20 to 40 Gy)
CNS42	Young age at initial therapy (glioma); ≥ age 5 at initial therapy (meningioma)	CNS radiation
Sarcoma38	Primary diagnosis of soft tissue sarcoma; history of other subsequent neoplasm; family history of cancer	Radiation therapy; higher anthracycline dose (> 100 mg/m2); higher alkylating agent dose (alkylators score ≥ 2)
Nonmelanoma skin cancer43	White race; older attained age; primary diagnosis of HD; family history of skin cancer	Radiation therapy