TABLE II. EFFECT OF REGENERATING LIVER EXTRACTS ON LIVER REGENERATION TWO DAYS AFTER 44 PER CENT PARTIAL HEPATECTOMY IN DOGS.
| —Experiments— | Treatment | Labeled hepatocytes per 1,000 hepatocytes, mean ± S.D. | p Value cf. unmodified 44 percent hepatectomy | Mitoses per 1,000 hepatocytes, mean ± S.D. | p Value cf. unmodified 44 per cent hepatectomy | Cell size, units, mean ± S.D. | p Value cf. unmodified 44 percent hepatectomy | |
|---|---|---|---|---|---|---|---|---|
| Group | No. | |||||||
| A | 6 | No infusion | 6.42±1.31 | — | 0.62±0.13 | — | 0.181 ±0.26 | — |
| ———SALINE SOLUTION INTRAPORTALLY——— | ||||||||
| 1 | 6 | Saline solution | 6.53±1.06 | N.S. | 0.68±0.15 | N.S. | 0.178±0.019 | N.S. |
| ———LE INTRAPORTALLY——— | ||||||||
| 2 | 6 | Normal liver | 6.28±1.47 | N.S. | 0.58±0.18 | N.S. | 0.171±0.019 | N.S. |
| 3 | 6 | 24 hr. regenerating | 6.71 ±0.85 | N.S. | 0.67±0.13 | N.S. | 0.179±0.018 | N.S. |
| 4 | 6 | 48 hr. regenerating | 8.20±1.64 | N.S. | 0.78±0.21 | N.S. | 0.187±0.030 | N.S. |
| 5 | 6 | 72 hr. regenerating | 9.86±1.86 | =0.004 | 1.03±0.13 | <0.001 | 0.192±0.022 | N.S. |
| ———LE INTRAPERITONEALLY——— | ||||||||
| 6 | 3 | Normal liver | 6.10±1.90 | N.S. | 0.59±0.22 | N.S. | 0.173±0.037 | N.S. |
| 7 | 4 | 24 hr. regenerating | 6.60±1.89 | N.S. | 0.61±0.19 | N.S. | 0.177±0.021 | N.S. |
| 8 | 2 | 48 hr. regenerating | 9.50±1.27 | <0.05 | 0.90±0.13 | <0.05 | 0.186±0.017 | N.S. |
| 9 | 2 | 72 hr. regenerating | 8.10±2.40 | N.S. | 0.79±0.15 | N.S. | 0.183±0.024 | N.S. |
| ———LE INTRAVENOUSLY——— | ||||||||
| 10 | 2 | 48 hr. regenerating | 6.70±0.84 | N.S. | 0.60±0.06 | N.S. | 0.158±0.010 | 0.05<p<0.1 |
| ———INSULIN INTRAPORTALLY——— | ||||||||
| 11 | 4 | 0.16 units/kgm. | 6.55±0.58 | N.S. | 0.66±0.18 | N.S. | 0.180±0.014 | N.S. |
| 12 | 4 | 0.64 units/kgm. | 6.50±0.89 | N.S. | 0.67±0.09 | N.S. | 0.179±0.017 | N.S. |
LE, Liver extract.
N.S., Not significant.