TABLE III. EFFECT OF REGENERATING LIVER EXTRACTS IN LIVER REGENERATION THREE DAYS AFTER 44 PER CENT PARTIAL HEPATECTOMY IN DOGS.
| —Experiments— | Treatment | Labeled hepatocytes per 1,000 hepatocytes, mean ± S.D. | p Value cf. unmodified 44 per cent hepatectomy | Mitoses per 1,000 hepatocytes, mean ± S.D. | p Value cf. unmodified 44 per cent hepatectomy | Cell size, units, mean ± S.D. | p Value cf. unmodified 44 per cent hepatectomy | |
|---|---|---|---|---|---|---|---|---|
| Group | No. | |||||||
| B | 6 | No infusion | 9.60±0.81 | — | 0.90±0.11 | — | 0.192±0.026 | — |
| ———SALINE SOLUTION INTRAPORTALLY——— | ||||||||
| 13 | 6 | Saline solution | 9.47±1.13 | N.S. | 0.88±0.20 | N.S. | 0.189±0.026 | N.S. |
| ———LE INTRAPORTALLY——— | ||||||||
| 14 | 6 | Normal liver | 8.98±1.83 | N.S. | 0.82±0.18 | N.S. | 0.186±0.026 | N.S. |
| 15 | 6 | 24 hr. regenerating | 9.53±0.95 | N.S. | 0.92±0.17 | N.S. | 0.199±0.039 | N.S. |
| 16 | 7 | 48 hr. regenerating | 10.06±1.75 | N.S. | 0.96±0.21 | N.S. | 0.194±0.020 | N.S. |
| 17 | 7 | 72 hr. regenerating | 14.07±3.15 | =0.004 | 1.61±0.31 | <0.001 | 0.198±0.044 | N.S. |
| ———LE INTRAPERITONEALLY——— | ||||||||
| 18 | 2 | Normal liver | 9.00±3.25 | N.S. | 0.88±0.41 | N.S. | 0.187±0.031 | N.S. |
| 19 | 2 | 24 hr. regenerating | 9.25±0.64 | N.S. | 0.85±0.06 | N.S. | 0.180±0.017 | N.S. |
| 20 | 2 | 48 hr. regenerating | 9.55±1.77 | N.S. | 0.85±0.09 | N.S. | 0.190±0.017 | N.S. |
| 21 | 2 | 72 hr. regenerating | 9.35±2.62 | N.S. | 0.85±0.21 | N.S. | 0.203±0.028 | N.S. |
| ———LE INTRAVENOUSLY——— | ||||||||
| 22 | 2 | 48 hr. regenerating | 8.05±0.21 | =0.005 | 0.71±0.12 | 0.05<p<0.1 | 0.196±0.031 | N.S. |
| ———INSULIN INTRAPORTALLY——— | ||||||||
| 23 | 4 | 0.16 units/kgm. | 9.53±0.99 | N.S. | 0.86±0.08 | N.S. | 0.191±0.015 | N.S. |
| 24 | 4 | 0.64 units/kgm. | 9.60±1.25 | N.S. | 0.89±0.11 | N.S. | 0.190±0.023 | N.S. |
LE, Liver extract.
N.S., Not significant.