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. Author manuscript; available in PMC: 2009 May 6.
Published in final edited form as: Mol Cell Endocrinol. 2006 Oct 19;260-262:109–116. doi: 10.1016/j.mce.2006.03.046

Fig 8.

Fig 8

A model for the post-transcriptional regulation of LH receptor in the ovary. Binding of LH or hCG activates cAMP signal cascade and results in steroid hormone biosynthesis followed by a depletion of ovarian cholesterol. This triggers an increase in transcription of genes associated with synthesis and transport of plasma cholesterol. Mevalonate kinase (MVK), one of the enzymes involved in cholesterol biosynthesis at this time binds to the LH receptor mRNA and leads to its degradation and subsequent down-regulation of receptor expression on the cell surface.