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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Methods Mol Biol. 2009;487:267–281. doi: 10.1007/978-1-60327-547-7_13

Figure 3. The uPAR system.

Figure 3

The uPAR-uPA system deals with uPA and its receptor uPAR. Pro-uPA is activated to active uPA, which in turn, activates plasminogen to plasmin, thereby activating multiple proteases. uPAR is known to be associated with integrins, which initiate multiple survival intracellular signals in cancer cells.