Rearing counts over time (A) following first injection and (B) at 14 days of withdrawal, in response to a challenge of 2.5 mg/kg, i.p. amphetamine (sensitized and non-sensitized groups), or saline. (C) Total rearing during first exposure and at 14 days of withdrawal, during the 60 min observation period. * represents significant differences between sensitized and non-sensitized rats, # represents significant differences from pre-test. Both amphetamine-treated groups were significantly higher in total rearing than saline-treated rats at 14 days of withdrawal, but only non-sensitized rats were significantly higher compared to saline-treated rats in the first exposure test (see Results for statistics). (Amphetamine-sensitized: N=10, non-sensitized: N=6, saline: N=16; means ± S.E.M. are shown for all groups).