Table 4.
Basal concentrations of serotonin within the limbic and nigrostriatal systems 17 days following repeated amphetamine (2.5 mg/kg, ip.) or saline pre-treatment
| 5-HT Concentrations (pg/µg tissue) | ||||
|---|---|---|---|---|
| Region | Treatment | Mean±SEM | F | p |
| Central Nucleus of the Amygdala |
Sensitized | 21.4±2.0 | 0.965 | 0.397 |
| Non-Sensitized | 23.3±2.3 | |||
| Control | 26.3±2.6 | |||
| Median Raphe Nucleus |
Sensitized | 52.1±4.3 | 1.590 | 0.226 |
| Non-Sensitized | 68.2±6.3 | |||
| Control | 58.1±3.4 | |||
| Nucleus Accumbens Core |
Sensitized | 9.6±0.2 | 0.777 | 0.472 |
| Non-Sensitized | 9.3±0.4 | |||
| Control | 10.1±0.4 | |||
| Substantia Nigra |
Sensitized | 15.6±1.2 | 1.017 | 0.378 |
| Non-Sensitized | 14.0±1.3 | |||
| Control | 16.5±1.0 | |||
| Ventral Hippocampus |
Sensitized | 9.9±0.6 | 2.130 | 0.140 |
| Non-Sensitized | 8.0±0.7 | |||
| Control | 8.7±0.5 | |||