Table 5.
Basal concentrations of 5-HIAA within the limbic and nigrostriatal systems 17 days following repeated amphetamine (2.5 mg/kg, ip.) or saline pre-treatment.
| 5-HIAA Concentrations (pg/µg tissue) | ||||
|---|---|---|---|---|
| Region | Treatment | Mean±SEM | F | p |
| Central Nucleus of the Amygdala |
Sensitized | 16.1±01.3 | 1.712 | 0.201 |
| Non-Sensitized | 20.3±02.0 | |||
| Control | 18.7±01.2 | |||
| Medial Prefrontal Cortex |
Sensitized | 4.4±00.2 | 1.079 | 0.353 |
| Non-Sensitized | 4.8±00.1 | |||
| Control | 4.9±00.3 | |||
| Dorsal Raphe Nucleus |
Sensitized | 61.7±04.2 | 1.423 | 0.261 |
| Non-Sensitized | 80.9±06.5 | |||
| Control | 70.7±05.4 | |||
| Median Raphe Nucleus |
Sensitized | 82.0±11.2 | 0.972 | 0.393 |
| Non-Sensitized | 106.9±04.9 | |||
| Control | 89.1±07.7 | |||
| Ventral Tegmental Area |
Sensitized | 17.0±00.6 | 1.559 | 0.227 |
| Non-Sensitized | 18.4±00.8 | |||
| Control | 18.7±00.7 | |||
| Nucleus Accumbens Shell |
Sensitized | 8.4±00.5 | 2.679 | 0.086 |
| Non-Sensitized | 7.5±00.7 | |||
| Control | 9.2±00.4 | |||
| Nucleus Accumbens Core |
Sensitized | 8.1±00.4 | 0.359 | 0.701 |
| Non-Sensitized | 8.4±00.6 | |||
| Control | 8.6±00.4 | |||
| Substantia Nigra |
Sensitized | 12.3±00.6 | 0.288 | 0.752 |
| Non-Sensitized | 13.5±01.3 | |||
| Control | 14.1±01.5 | |||
| Dorsal Striatum |
Sensitized | 6.4±00.5 | 2.720 | 0.085 |
| Non-Sensitized | 6.2±00.2 | |||
| Control | 7.5±00.4 | |||
| Dorsal Hippocampus |
Sensitized | 7.8±00.5 | 0.0815 | 0.922 |
| Non-Sensitized | 7.6±00.6 | |||
| Control | 7.6±00.4 | |||
| Ventral Hippocampus |
Sensitized | 8.3±00.9 | 0.951 | 0.400 |
| Non-Sensitized | 7.0±00.5 | |||
| Control | 7.7±00.3 | |||