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. Author manuscript; available in PMC: 2010 Mar 15.
Published in final edited form as: Cancer Res. 2009 Mar 10;69(6):2384–2392. doi: 10.1158/0008-5472.CAN-08-3953

Figure 2.

Figure 2

Structurally defined conformational states of the c-Src and Abl kinase domains. The P-loop is colored in red, helix αC is colored in orange and the activation loop is colored in blue. State A, active c-Src kinase Thr338Ile (PDB-entry 3DQW, (16)). State B, inactive Src/Cdk-like conformation (PDB-entry 1QCF) (32). State C, inactive Abl/c-Kit-like conformation (PDB-entry 1OPJ) (33) with the DFG motif in the flipped conformation relative to state A and B.