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. Author manuscript; available in PMC: 2010 Mar 15.
Published in final edited form as: Cancer Res. 2009 Mar 10;69(6):2384–2392. doi: 10.1158/0008-5472.CAN-08-3953

Figure 3.

Figure 3

Solvent exposure of inhibitors. Top panel. The structures of the Abl•imatinib (A, PDB-entry 1OPJ) (33), c-Src•imatinib (B, PDB-entry 2OIQ) (3) and Src•DSA8 (C) complexes are shown for comparison. The solvent accessible surface of the proteins is depicted in transparent gray. The P-loop is colored in red, helix αC is colored in orange and the activation loop is colored in blue. Each ring of imatinib and DSA8 has been labeled A-F in the structure representation (top panel) and the schematic drawing (bottom panel). Bottom panel. The solvent accessible area was calculated for the atoms shown in red for imatinib and DSA8 in each protein complex.